Macrocyclics has been actively developing new synthetic methodologies and cutting edge applications which have relied upon customized chelating agents since its inception. Macrocyclics has created an extensive IP portfolio and possesses world-recognized expertise in high performance chelation chemistries relevant to a broad spectrum of medical applications including bifunctional chelating agents, contrast enhancement media and molecular imaging.

Our most recent technologies include novel techniques for rapid labeling of biomolecules with chelating agents, paramagnetic magnetization transfer and pH responsive contrast agents. We believe these new areas of development will favorably position Macrocyclics for the new and emerging medical applications on the horizon.

New Technologies

US Patent 6,875,419
"Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use"

US Patent 6,852,854
"Preformed carboxylated active ester for labeling biomolecules"

US Patent 6,838,557
"Process for making a chelating agent for labeling biomolecules using preformed active esters"

US Patent 6,746,662
"pH sensitive MRI contrast agents"

Foundation Technologies

US Patent 5,834,456
"Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents"

US Patent 5,750,660
"Bicyclopolyazamacrocyclophosphonic acid half esters"

US Patent 5,739,294
"Bicyclopolyazamacrocyclophosphonic acid complexes for use as contrast agents"

US Patent 5,630,997
"Phosphorylated polyazamacrocyclic compounds for complexation of metal ions"

US Patent 5,480,990
"Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents"

US Patent 5,462,725
"2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents"

US Patent 5,428,139
"Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals"

US Patent 5,385,893
"Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents"

US Patent 5,362,476
"Alkyl phosphonate polyazamacrocyclic cheates for MRI"

US Patent 5,316,757
"Synthesis of polyazamacrocyles with more than one type of side-chain chelating group (MRI methods)"

US Patent 5,428,155
"Synthesis of polyazamacrocyles with more than on type of side-chain chelating group (synthetic method, composition)"

US Patent 5,188,816
"Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS"

US Patent 5,342,606
"Polyazamacrocyclic compounds for complexation of metal ions"

Interested in licensing our technology?

Please contact Garry Kiefer at 972-250-2248.